Last Updated

17 May 2022

Transmission dynamics of residual and re-emerging malaria in the Amazon: defining a roadmap to malaria elimination

Objectives

Cross-sectional surveys will be carried out in order to identify risk factors for residual malaria infection and disease at both the individual and household level, to supply parasite samples for detailed population-level molecular analyses and to supply epidemiological data for parameterization of new mathematical models of malaria transmission.

SPECIFIC AIMS:

  • Aim 1: Longitudinally determine malaria dynamics in a major residual malaria hotspot in Brazil.
  • Aim 2: Identify and quantify population changes in P. vivax and P. falciparum to detect reintroductions, and to estimate parasite population complexity at baseline and potentially after interventions.
  • Aim 3: Develop and apply mathematical models to describe changing dynamics of malaria incidence and parasitemia prevalence over time, and to assess potential effects of combinations of interventions on malaria control and elimination (e.g., insecticide-treated bednet distribution, larviciding or improved antirelapse therapy for vivax malaria).

Principal Institution(s)

Principal Investigator
Rationale and Abstract

The study will be developed in Mâncio Lima, a residual malaria hotspot in northwestern Brazil. The population of study is approximately 2,000 subjects aged 3 months and up, who correspond to all the residents of 20% of the households of the urban area of Mâncio Lima.

Clinical and epidemiological characteristics of malaria, genetic characteristics of the population of Plasmodium and changing dynamics of malaria transmission will be analyzed.

ClinicalTrials.gov Identifier: NCT03689036

Study Design

Study Type: Observational
Estimated Enrollment: 2000 participants
Observational Model: Cohort
Time Perspective: Prospective