Targeted Test and Treat (TTaT) strategies for malaria are defined by WHO as testing a sub-population at high risk of infection with a parasitologic test, and treating confirmed malaria cases to reduce transmission (risk factors include demographic, occupational and exposure characteristics). The WHO Global Malaria Programme is currently developing new Guidelines for Malaria Elimination to provide policy advice to countries, including recommendations on the implementation of TTaT interventions. With the aim of facilitating the work of the Malaria Elimination Guidelines Development Group, this deep dive compiles the landscape of recent and ongoing research in malaria TTaT strategies and provides an overview of the projects’ main characteristics.